3L2O
Structure-Based Mechanism of Dimerization-Dependent Ubiquitination by the SCFFbx4 Ubiquitin Ligase
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | S-phase kinase-associated protein 1 | polymer | 149 | 16827.1 | 1 | UniProt (P63208) Pfam (PF03931) Pfam (PF01466) In PDB | Homo sapiens (human) | Cyclin A/CDK2-associated protein p19, p19skp1, p19A, RNA polymerase II elongation factor-like protein, Organ of Corti protein 2, OCP-2, OCP-II, Transcription elongation factor B, SIII |
2 | B | F-box only protein 4 | polymer | 312 | 35848.7 | 1 | UniProt (Q9UKT5) Pfam (PF00646) In PDB | Homo sapiens (human) | |
3 | water | water | 18.0 | 76 | Chemie (HOH) |
Sequence modifications
A: 1001 - 1163 (UniProt: P63208)
B: 55 - 387 (UniProt: Q9UKT5)
PDB | External Database | Details |
---|---|---|
Ala 1002 | Pro 2 | engineered mutation |
- | Asp 38 | deletion |
- | Asp 39 | deletion |
- | Glu 40 | deletion |
- | Gly 41 | deletion |
- | Asp 42 | deletion |
- | Asp 43 | deletion |
- | Pro 70 | deletion |
- | Pro 71 | deletion |
- | Pro 72 | deletion |
- | Glu 73 | deletion |
- | Asp 74 | deletion |
- | Asp 75 | deletion |
- | Glu 76 | deletion |
- | Asn 77 | deletion |
- | Lys 78 | deletion |
- | Glu 79 | deletion |
- | Lys 80 | deletion |
- | Arg 81 | deletion |
Gly 1078 | - | insertion |
Gly 1079 | - | insertion |
Ser 1080 | - | insertion |
Gly 1081 | - | insertion |
PDB | External Database | Details |
---|---|---|
- | Thr 150 | deletion |
- | Arg 151 | deletion |
- | Arg 152 | deletion |
- | Ala 153 | deletion |
- | Ser 154 | deletion |
- | Lys 155 | deletion |
- | Ser 156 | deletion |
- | Ser 157 | deletion |
- | Arg 158 | deletion |
- | Pro 159 | deletion |
- | Met 160 | deletion |
- | Tyr 161 | deletion |
- | Gly 162 | deletion |
- | Ala 163 | deletion |
- | Val 164 | deletion |
- | Thr 165 | deletion |
- | Ser 166 | deletion |
- | Phe 167 | deletion |
- | Leu 168 | deletion |
- | His 169 | deletion |
- | Ser 170 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 52675.8 | |
All* | Total formula weight | 52675.8 |