3L1S
3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Glycogen synthase kinase-3 beta | polymer | 414 | 46114.4 | 2 | UniProt (P49841) Pfam (PF00069) In PDB | Homo sapiens (human) | GSK-3 beta |
| 2 | A, B | (4E)-4-[(4-chlorophenyl)hydrazono]-5-(3,4-dimethoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one | non-polymer | 358.8 | 2 | Chemie (Z92) | |||
| 3 | B | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | water | water | 18.0 | 407 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 92228.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 812.5 | |
| All* | Total formula weight | 93041.3 |
