3KY2

Crystal structure of Fibroblast Growth Factor Receptor 1 kinase domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Basic fibroblast growth factor receptor 1	polymer	317	36226.6	2	UniProt (P11362) Pfam (PF07714)	Homo sapiens (human)	FGFR-1, bFGF-R, Fms-like tyrosine kinase 2, c-fgr
2	C, D, E, F (A, B)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
3	G, H (A, B)	water	water		18.0	247	Chemie (HOH)

Sequence modifications

A, B: 458 - 765 (UniProt: P11362)

PDB	External Database	Details
Met 449	-	expression tag
Gly 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
Met 457	-	expression tag
Ala 488	Cys 488	engineered mutation
Ser 584	Cys 584	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72453.2
Non-Polymers*	Number of molecules	4
	Total formula weight	384.3
All*	Total formula weight	72837.5

*Water molecules are not included.