3KXZ
The complex crystal structure of LCK with a probe molecule w259
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proto-oncogene tyrosine-protein kinase LCK | polymer | 287 | 33209.7 | 1 | UniProt (P06239) Pfam (PF07714) | Homo sapiens (human) | Lymphocyte cell-specific protein-tyrosine kinase, p56-LCK, LSK, T cell-specific protein-tyrosine kinase |
| 2 | B (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | SULFATE ION | ||
| 3 | C (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | CALCIUM ION | ||
| 4 | D (A) | 3-[7-[(3-hydroxyphenyl)amino]pyrazolo[1,5-a]pyrimidin-2-yl]-N-(1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-yl)benzamide | non-polymer | 500.6 | 1 | Chemie (925) | WAC-597259 | ||
| 5 | E (A) | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A: 225 - 509 (UniProt: P06239)
| PDB | External Database | Details |
|---|---|---|
| Gly 223 | - | expression tag |
| Ser 224 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33209.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 636.7 | |
| All* | Total formula weight | 33846.5 |
