3KSQ
Discovery of C-Imidazole Azaheptapyridine FPT Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Farnesyltransferase, CAAX box, alpha | polymer | 377 | 44086.1 | 1 | UniProt (Q5RKJ4) Pfam (PF01239) UniProt (by SIFTS) (Q04631) | Rattus norvegicus (rat) | |
| 2 | B (B) | Protein farnesyltransferase subunit beta | polymer | 437 | 48722.3 | 1 | UniProt (Q02293) Pfam (PF00432) | Rattus norvegicus (rat) | FTase-beta, CAAX farnesyltransferase subunit beta, Ras proteins prenyltransferase subunit beta |
| 3 | C (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (B) | FARNESYL DIPHOSPHATE | non-polymer | 382.3 | 1 | Chemie (FPP) | |||
| 6 | F (B) | tert-butyl 4-{(11S)-8-chloro-6-[(R)-hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl}piperazine-1-carboxylate | non-polymer | 522.0 | 1 | Chemie (Z96) | |||
| 7 | G, H (A, B) | water | water | 18.0 | 299 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 92808.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 994.1 | |
| All* | Total formula weight | 93802.4 |
