3KS9
Metabotropic glutamate receptor mGluR1 complexed with LY341495 antagonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Metabotropic glutamate receptor 1 | polymer | 496 | 55689.1 | 2 | UniProt (Q13255) Pfam (PF01094) | Homo sapiens (human) | mGluR1 |
| 2 | C, G (A, B) | 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine | non-polymer | 353.4 | 2 | Chemie (Z99) PubChem (44300270) PubChem (44348804) PubChem (57824323) PubChem (4364840) PubChem (69351741) PubChem (68198047) PubChem (89651894) PubChem (6604829) PubChem (9819927) PubChem (9975366) PubChem (10618042) PubChem (10713043) PubChem (10807972) PubChem (138113521) PubChem (156758060) PubChem (163320174) PubChem (169545577) PubChem (171041419) | |||
| 3 | D, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 4 | E, F (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 651 | Chemie (HOH) |
Sequence modifications
A, B: 28 - 518 (UniProt: Q13255)
| PDB | External Database | Details |
|---|---|---|
| Ser 254 | Cys 254 | engineered mutation |
| Leu 519 | - | expression tag |
| Val 520 | - | expression tag |
| Pro 521 | - | expression tag |
| Arg 522 | - | expression tag |
| Gly 523 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 111378.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1197.8 | |
| All* | Total formula weight | 112576.1 |
