3KRR
Crystal Structure of JAK2 complexed with a potent quinoxaline ATP site inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase JAK2 | polymer | 295 | 34722.5 | 1 | UniProt (O60674) Pfam (PF07714) | Homo sapiens (human) | Janus kinase 2, JAK-2 |
| 2 | B (A) | 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1H-pyrazol-4-yl)quinoxaline | non-polymer | 490.5 | 1 | Chemie (DQX) | |||
| 3 | C (A) | water | water | 18.0 | 191 | Chemie (HOH) |
Sequence modifications
A: 840 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Gly 838 | - | expression tag |
| Ser 839 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34722.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 490.5 | |
| All* | Total formula weight | 35213.0 |
