3KKA

Co-crystal structure of the sam domains of EPHA1 AND EPHA2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	EPHRIN TYPE-A RECEPTOR 1	polymer	82	9559.9	2	UniProt (P21709) Pfam (PF00536)	HOMO SAPIENS (HUMAN)	TYROSINE-PROTEIN KINASE RECEPTOR EPH
2	C, D, E (C, D, E)	EPHRIN TYPE-A RECEPTOR 2	polymer	86	10063.5	3	UniProt (P29317) Pfam (PF00536)	HOMO SAPIENS (HUMAN)	TYROSINE-PROTEIN KINASE RECEPTOR ECK, EPITHELIAL CELL KINASE
3	F (B)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
4	G, H, I, J, K (A, B, C, D, E)	water	water		18.0	34	Chemie (HOH)

Sequence modifications

A, B: 911 - 974 (UniProt: P21709)

PDB	External Database	Details
Met 893	-	expression tag
His 894	-	expression tag
His 895	-	expression tag
His 896	-	expression tag
His 897	-	expression tag
His 898	-	expression tag
His 899	-	expression tag
Ser 900	-	expression tag
Ser 901	-	expression tag
Gly 902	-	expression tag
Arg 903	-	expression tag
Glu 904	-	expression tag
Asn 905	-	expression tag
Leu 906	-	expression tag
Tyr 907	-	expression tag
Phe 908	-	expression tag
Gln 909	-	expression tag
Gly 910	-	expression tag

C, D, E: 902 - 970 (UniProt: P29317)

PDB	External Database	Details
Met 885	-	expression tag
His 886	-	expression tag
His 887	-	expression tag
His 888	-	expression tag
His 889	-	expression tag
His 890	-	expression tag
His 891	-	expression tag
Ser 892	-	expression tag
Ser 893	-	expression tag
Gly 894	-	expression tag
Arg 895	-	expression tag
Glu 896	-	expression tag
Asn 897	-	expression tag
Leu 898	-	expression tag
Tyr 899	-	expression tag
Phe 900	-	expression tag
Gln 901	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	49310.2
Non-Polymers*	Number of molecules	1
	Total formula weight	35.5
All*	Total formula weight	49345.7

*Water molecules are not included.