3KJQ
Caspase 8 with covalent inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Caspase-8 | polymer | 164 | 18640.1 | 1 | UniProt (Q14790) Pfam (PF00656) In PDB | Homo sapiens (human) | CASP-8, ICE-like apoptotic protease 5, MORT1-associated CED-3 homolog, MACH, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, Caspase-8 subunit p18, Caspase-8 subunit p10 |
2 | B | Caspase-8 | polymer | 95 | 10901.4 | 1 | UniProt (Q14790) Pfam (PF00656) In PDB | Homo sapiens (human) | CASP-8, ICE-like apoptotic protease 5, MORT1-associated CED-3 homolog, MACH, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, Caspase-8 subunit p18, Caspase-8 subunit p10 |
3 | A | (3S)-3-({[(5S,8R)-2-(3-carboxypropyl)-8-(2-{[(4-chlorophenyl)acetyl]amino}ethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl}amino)-4-oxopentanoic acid | non-polymer | 592.0 | 2 | Chemie (B94) | |||
4 | water | water | 18.0 | 146 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 29541.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1184.0 | |
All* | Total formula weight | 30725.5 |