3KJN
Caspase 8 bound to a covalent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Caspase-8 | polymer | 164 | 18640.1 | 1 | UniProt (Q14790) Pfam (PF00656) | Homo sapiens (human) | CASP-8, ICE-like apoptotic protease 5, MORT1-associated CED-3 homolog, MACH, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, FLICE, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, Caspase-8 subunit p18, Caspase-8 subunit p10 |
| 2 | B (B) | Caspase-8 | polymer | 95 | 10901.4 | 1 | UniProt (Q14790) Pfam (PF00656) | Homo sapiens (human) | CASP-8, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, Caspase-8 subunit p18, Caspase-8 subunit p10 |
| 3 | C (A) | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 1 | Chemie (DTT) | |||
| 4 | D (A) | (3S)-3-({[(5S)-2-{2-[(1H-benzimidazol-5-ylcarbonyl)amino]ethyl}-7-(cyclohexylmethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl}amino)-4-oxopentanoic acid | non-polymer | 593.6 | 1 | Chemie (B93) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 243 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29541.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 747.9 | |
| All* | Total formula weight | 30289.4 |
