3KJ0
Mcl-1 in complex with Bim BH3 mutant I2dY
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 158 | 17937.4 | 1 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (human) | Bcl-2-related protein EAT/mcl1, mcl1/EAT, Bcl-2-like protein 3, Bcl2-L-3 |
| 2 | B (B) | Bcl-2-like protein 11 | polymer | 27 | 3179.5 | 1 | UniProt (O43521) Pfam (PF08945) | Homo sapiens (human) | Bcl2-L-11, Bcl2-interacting mediator of cell death |
| 3 | C (B) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 139 | Chemie (HOH) |
Sequence modifications
A: 172 - 327 (UniProt: Q07820)
B: 1 - 23 (UniProt: O43521)
| PDB | External Database | Details |
|---|---|---|
| Gly 170 | - | expression tag |
| Ser 171 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Tyr 6 | Ile 148 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21116.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 122.1 | |
| All* | Total formula weight | 21239.0 |
