3KG2

AMPA subtype ionotropic glutamate receptor in complex with competitive antagonist ZK 200775

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Glutamate receptor 2	polymer	823	92043.0	4	UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (rat)	GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, AMPA-selective glutamate receptor 2
2	E, F	beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB GlyTouCan (G31886NL)
3	G, H	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
4	A, B, C, D	{[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid	non-polymer		409.3	4	Chemie (ZK1)

Sequence modifications

A, B, C, D: 10 - 826 (UniProt: P19491)

PDB	External Database	Details
Glu 241	Asn 256	engineered mutation
-	Val 397	deletion
-	Thr 398	deletion
-	Leu 402	deletion
-	Pro 403	deletion
-	Ser 404	deletion
-	Gly 405	deletion
Asp 385	Asn 406	engineered mutation
Gln 392	Asn 413	engineered mutation
Ala 410	Lys 431	engineered mutation
Ala 413	Glu 434	engineered mutation
Ala 414	Met 435	engineered mutation
Ala 416	Glu 437	engineered mutation
Ala 589	Cys 610	engineered mutation
Thr 744	Asn 765	variant
Pro 745	Ala 766	variant
Ser 754	Asn 775	variant

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	368172.2
Branched	Number of molecules	4
	Total formula weight	2670.4
Non-Polymers*	Number of molecules	4
	Total formula weight	1637.0
All*	Total formula weight	372479.6

*Water molecules are not included.