3KEC
Crystal Structure of Human MMP-13 complexed with a phenyl-2H-tetrazole compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Collagenase 3 | polymer | 167 | 18780.0 | 2 | UniProt (P45452) Pfam (PF00413) In PDB | Homo sapiens (human) | Matrix metalloproteinase-13, MMP-13 |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | A, B | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 4 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | A, B | 4-{[({3-[2-(4-methoxybenzyl)-2H-tetrazol-5-yl]phenyl}carbonyl)amino]methyl}benzoic acid | non-polymer | 443.5 | 2 | Chemie (3KE) | |||
| 6 | A, B | ACETOHYDROXAMIC ACID | non-polymer | 75.1 | 2 | Chemie (HAE) | |||
| 7 | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence modifications
A, B: 105 - 267 (UniProt: P45452)
| PDB | External Database | Details |
|---|---|---|
| Tyr 104 | - | expression tag |
| Pro 268 | - | expression tag |
| Gly 269 | - | expression tag |
| Asp 270 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 37559.9 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1731.3 | |
| All* | Total formula weight | 39291.2 |
