3KCF
Crystal structure of TGFbRI complexed with a pyrazolone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | TGF-beta receptor type-1 | polymer | 342 | 38920.6 | 5 | UniProt (P36897) Pfam (PF08515) Pfam (PF00069) | Homo sapiens (human) | Transforming growth factor-beta receptor type I, TGF-beta receptor type I, TGF-beta type I receptor, TbetaR-I, TGFR-1, Serine/threonine-protein kinase receptor R4, SKR4, Activin receptor-like kinase 5, ALK-5 |
| 2 | F, J, N, P, T (A, B, C, D, E) | 4-[3-(methoxymethyl)phenyl]-1,2-dimethyl-5-quinoxalin-6-yl-1,2-dihydro-3H-pyrazol-3-one | non-polymer | 360.4 | 5 | Chemie (JZO) | |||
| 3 | G, H, I, K, L... (A, B, C, D, E) | PHOSPHATE ION | non-polymer | 95.0 | 13 | Chemie (PO4) | |||
| 4 | X, Y, Z (A, C, E) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 194603.2 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3036.7 | |
| All* | Total formula weight | 197639.9 |
