3KB7
Crystal structure of Polo-like kinase 1 in complex with a pyrazoloquinazoline inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase PLK1 | polymer | 311 | 35659.5 | 1 | UniProt (P53350) Pfam (PF00069) | Homo sapiens (human) | Polo-like kinase 1, PLK-1, Serine/threonine-protein kinase 13, STPK13 |
| 2 | B (A) | 8-{[2-methoxy-5-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | non-polymer | 448.5 | 1 | Chemie (071) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | L(+)-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (TLA) | |||
| 5 | E (A) | water | water | 18.0 | 75 | Chemie (HOH) |
Sequence modifications
A: 36 - 345 (UniProt: P53350)
| PDB | External Database | Details |
|---|---|---|
| Gly 35 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35659.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 664.0 | |
| All* | Total formula weight | 36323.6 |
