3KA0
MK2 complex with inhibitor 6-(5-(2-aminopyrimidin-4-ylamino)-2-hydroxyphenyl)-N-methylbenzo[b]thiophene-2-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MAP kinase-activated protein kinase 2 | polymer | 320 | 36987.7 | 1 | UniProt (P49137) Pfam (PF00069) | Homo sapiens (human) | MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAPK-2, MK2 |
| 2 | B (A) | 6-{5-[(2-aminopyrimidin-4-yl)amino]-2-hydroxyphenyl}-N-methylidene-1-benzothiophene-2-carboxamide | non-polymer | 389.4 | 1 | Chemie (MK3) | |||
| 3 | C (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 47 - 366 (UniProt: P49137)
| PDB | External Database | Details |
|---|---|---|
| Glu 222 | Thr 222 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36987.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 389.4 | |
| All* | Total formula weight | 37377.1 |
