3K5D
Crystal Structure of BACE-1 in complex with AHM178
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Beta-secretase 1 | polymer | 408 | 45435.0 | 3 | UniProt (P56817) Pfam (PF00026) In PDB | Homo sapiens (human) | Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Membrane-associated aspartic protease 2, Memapsin-2, Aspartyl protease 2, Asp 2, ASP2 |
| 2 | A, B, C | N-acetyl-L-leucyl-N-[(4S,5S,7R)-8-(butylamino)-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]-L-methioninamide | non-polymer | 544.8 | 3 | BIRD (PRD_000675) Chemie (XLI) | |||
| 3 | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A, B, C: 35 - 392 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Gly 33 | - | expression tag |
| Pro 34 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 136304.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1634.4 | |
| All* | Total formula weight | 137939.2 |
