3K3B
Co-crystal structure of the human kinesin Eg5 with a novel tetrahydro-beta-carboline
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Kinesin-like protein KIF11 | polymer | 368 | 41055.6 | 2 | UniProt (P52732) Pfam (PF00225) | Homo sapiens (human) | Kinesin-related motor protein Eg5, Kinesin-like spindle protein HKSP, Thyroid receptor-interacting protein 5, TRIP-5, Kinesin-like protein 1 |
| 2 | C, J (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, K (A, B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 4 | E, L (A, B) | 3-[(1R)-2-acetyl-6-methyl-2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl]phenol | non-polymer | 320.4 | 2 | Chemie (L31) | |||
| 5 | F, I (A, B) | NITRATE ION | non-polymer | 62.0 | 2 | Chemie (NO3) | |||
| 6 | G (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | H (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 8 | M, N (A, B) | water | water | 18.0 | 309 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82111.2 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1809.4 | |
| All* | Total formula weight | 83920.5 |
