3JS2
Crystal structure of minimal kinase domain of fibroblast growth factor receptor 1 in complex with 5-(2-thienyl)nicotinic acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Basic fibroblast growth factor receptor 1 | polymer | 317 | 36226.6 | 2 | UniProt (P11362) Pfam (PF07714) In PDB | Homo sapiens (human) | FGFR-1, bFGF-R, Fms-like tyrosine kinase 2, c-fgr |
2 | A, B | 5-(2-thienyl)nicotinic acid | non-polymer | 205.2 | 2 | Chemie (VM1) | |||
3 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
4 | water | water | 18.0 | 142 | Chemie (HOH) |
Sequence modifications
A, B: 458 - 765 (UniProt: P11362)
PDB | External Database | Details |
---|---|---|
Met 449 | - | expression tag |
Gly 450 | - | expression tag |
His 451 | - | expression tag |
His 452 | - | expression tag |
His 453 | - | expression tag |
His 454 | - | expression tag |
His 455 | - | expression tag |
His 456 | - | expression tag |
Met 457 | - | expression tag |
Ala 488 | Cys 489 | engineered mutation |
Ser 584 | Cys 585 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 72453.2 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 600.4 | |
All* | Total formula weight | 73053.6 |