3JD8
cryo-EM structure of the full-length human NPC1 at 4.4 angstrom
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Niemann-Pick C1 protein | polymer | 1278 | 142272.9 | 1 | UniProt (O15118) Pfam (PF16414) Pfam (PF22314) Pfam (PF12349) Pfam (PF02460) | Homo sapiens (human) | |
| 2 | B, C, E (B, C, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 3 | D (D) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | F (F) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 5 | G, H, I, J, K... (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 11 | Chemie (NAG) | |||
| 6 | R (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 142272.9 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2608.4 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2819.9 | |
| All* | Total formula weight | 147701.3 |
