3J42
Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Envelope protein E | polymer | 390 | 43400.9 | 3 | UniProt (O11875) Pfam (PF00869) Pfam (PF02832) | Dengue virus 2 | |
| 2 | D, E, F (D, E, F) | PrM | polymer | 81 | 9261.5 | 3 | UniProt (Q3BCY5) Pfam (PF01570) | Dengue virus 2 | |
| 3 | G, I, K (G, I, K) | Ig heavy chain V region MOPC 21, Igh protein chimera | polymer | 221 | 23696.6 | 3 | UniProt (P01783) UniProt (Q6PIP8) Pfam (PF07686) Pfam (PF07654) | Mus musculus (mouse) | 2H2 heavy chain Fab |
| 4 | H, J, L (H, J, L) | Ig kappa chain V-V region MOPC 21, Anti-colorectal carcinoma light chain chimera | polymer | 212 | 23355.7 | 3 | UniProt (P01634) UniProt (Q7TS98) Pfam (PF07686) Pfam (PF07654) | Mus musculus (mouse) | 2H2 light chain Fab |
Sequence modifications
A, B, C: 1 - 395 (UniProt: O11875)
G, I, K: 1 - 103 (UniProt: P01783)
G, I, K: 106 - 216 (UniProt: Q6PIP8)
H, J, L: 1001 - 1107 (UniProt: P01634)
H, J, L: 1108 - 1212 (UniProt: Q7TS98)
| PDB | External Database | Details |
|---|---|---|
| Ile 6 | Met 286 | conflict |
| - | Gly 297 | deletion |
| - | Gly 298 | deletion |
| - | Gln 332 | deletion |
| Val 139 | Ile 419 | conflict |
| Val 162 | Ile 442 | conflict |
| - | Phe 473 | deletion |
| - | Asn 474 | deletion |
| Asp 390 | Asn 670 | conflict |
G, I, K: 106 - 216 (UniProt: Q6PIP8)
| PDB | External Database | Details |
|---|---|---|
| His 104 | - | linker |
| Tyr 105 | - | linker |
| Gly 180 | Asp 194 | conflict |
| Thr 199 | Ser 213 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 1030 | Val 59 | conflict |
| Ser 1091 | Gly 120 | conflict |
| Thr 1094 | Tyr 123 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 299144.2 | |
| All* | Total formula weight | 299144.2 |
