3J42

Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Envelope protein E	polymer	390	43400.9	3	UniProt (O11875) Pfam (PF00869) Pfam (PF02832) In PDB	Dengue virus 2
2	D, E, F	PrM	polymer	81	9261.5	3	UniProt (Q3BCY5) Pfam (PF01570) In PDB	Dengue virus 2
3	G, I, K	Ig heavy chain V region MOPC 21, Igh protein chimera	polymer	221	23696.6	3	UniProt (P01783) UniProt (Q6PIP8) Pfam (PF07686) Pfam (PF07654) In PDB	Mus musculus (mouse)	2H2 heavy chain Fab
4	H, J, L	Ig kappa chain V-V region MOPC 21, Anti-colorectal carcinoma light chain chimera	polymer	212	23355.7	3	UniProt (P01634) UniProt (Q7TS98) Pfam (PF07686) Pfam (PF07654) In PDB	Mus musculus (mouse)	2H2 light chain Fab

Sequence modifications

A, B, C: 1 - 395 (UniProt: O11875)

PDB	External Database	Details
Ile 6	Met 286	CONFLICT
-	Gly 297	DELETION
-	Gly 298	DELETION
-	Gln 332	DELETION
Val 139	Ile 419	CONFLICT
Val 162	Ile 442	CONFLICT
-	Phe 473	DELETION
-	Asn 474	DELETION
Asp 390	Asn 670	CONFLICT

G, I, K: 1 - 103 (UniProt: P01783)
G, I, K: 106 - 216 (UniProt: Q6PIP8)

PDB	External Database	Details
His 104	-	LINKER
Tyr 105	-	LINKER
Gly 180	Asp 194	CONFLICT
Thr 199	Ser 213	CONFLICT

H, J, L: 1001 - 1107 (UniProt: P01634)

PDB	External Database	Details
Gly 1030	Val 59	CONFLICT
Ser 1091	Gly 120	CONFLICT
Thr 1094	Tyr 123	CONFLICT

H, J, L: 1108 - 1212 (UniProt: Q7TS98)

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	299144.2
All*	Total formula weight	299144.2

*Water molecules are not included.