3IW4
Crystal structure of PKC alpha in complex with NVP-AEB071
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Protein kinase C alpha type | polymer | 360 | 41571.4 | 3 | UniProt (P17252) Pfam (PF00069) Pfam (PF00433) In PDB | Homo sapiens (human) | PKC-alpha, PKC-A |
| 2 | A, B, C | 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]-1H-pyrrole-2,5-dione | non-polymer | 438.5 | 3 | Chemie (LW4) | |||
| 3 | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
A, B, C: 320 - 672 (UniProt: P17252)
| PDB | External Database | Details |
|---|---|---|
| Met 319 | - | cloning artifact |
| Glu 497 | Thr 497 | engineered mutation |
| His 673 | - | expression tag |
| His 674 | - | expression tag |
| His 675 | - | expression tag |
| His 676 | - | expression tag |
| His 677 | - | expression tag |
| His 678 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 124714.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1315.4 | |
| All* | Total formula weight | 126029.6 |
