3IUG

Crystal structure of the RhoGAP domain of RICS

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Rho/Cdc42/Rac GTPase-activating protein RICS	polymer	229	26300.0	2	UniProt (A7KAX9) Pfam (PF00620)	Homo sapiens (human)	p200RhoGAP, p250GAP, RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling, Brain-specific Rho GTPase-activating protein, GAB-associated Cdc42/Rac GTPase-activating protein, GC-GAP, GTPase regulator interacting with TrkA
2	C, D, E, F, G... (A, B)	UNKNOWN ATOM OR ION	non-polymer			11	Chemie (UNX)
3	N, O (A, B)	water	water		18.0	308	Chemie (HOH)

Sequence modifications

A, B: 367 - 577 (UniProt: A7KAX9)

PDB	External Database	Details
Met 349	-	expression tag
His 350	-	expression tag
His 351	-	expression tag
His 352	-	expression tag
His 353	-	expression tag
His 354	-	expression tag
His 355	-	expression tag
Ser 356	-	expression tag
Ser 357	-	expression tag
Gly 358	-	expression tag
Arg 359	-	expression tag
Glu 360	-	expression tag
Asn 361	-	expression tag
Leu 362	-	expression tag
Tyr 363	-	expression tag
Phe 364	-	expression tag
Gln 365	-	expression tag
Gly 366	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	52600.0
Non-Polymers*	Number of molecules	11
	Total formula weight	0.0
All*	Total formula weight	52600.0

*Water molecules are not included.