3IK3
AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase ABL1 | polymer | 288 | 33254.0 | 2 | UniProt (P00520) Pfam (PF07714) | Mus musculus (mouse) | Abelson murine leukemia viral oncogene homolog 1, c-ABL, p150 |
| 2 | C, D (A, B) | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | non-polymer | 532.6 | 2 | Chemie (0LI) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 459 | Chemie (HOH) |
Sequence modifications
A, B: 229 - 513 (UniProt: P00520)
| PDB | External Database | Details |
|---|---|---|
| Gly 228 | - | expression tag |
| Ile 315 | Thr 315 | engineered mutation |
| Gly 514 | - | expression tag |
| Thr 515 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66508.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1065.1 | |
| All* | Total formula weight | 67573.2 |
