3IAI
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Carbonic anhydrase 9 | polymer | 257 | 28172.7 | 4 | UniProt (Q16790) Pfam (PF00194) | Homo sapiens (human) | Carbonic anhydrase IX, CA-IX, CAIX, Carbonate dehydratase IX, Membrane antigen MN, P54/58N, Renal cell carcinoma-associated antigen G250, RCC-associated antigen G250, pMW1 |
| 2 | E, F, G, H (E, F, G, H) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 4 | In PDB GlyTouCan (G22768VO) | |||
| 3 | EA, I, NA, U (C, A, D, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | FA, J, OA, V (C, A, D, B) | 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE | non-polymer | 222.2 | 4 | Chemie (AZM) | |||
| 5 | AA, BA, GA, HA, IA... (B, C, A, D) | GLYCEROL | non-polymer | 92.1 | 25 | Chemie (GOL) | |||
| 6 | CA, LA, R, WA (B, C, A, D) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 4 | Chemie (TRS) | |||
| 7 | DA, MA, S, T, XA (B, C, A, D) | PHOSPHATE ION | non-polymer | 95.0 | 5 | Chemie (PO4) | |||
| 8 | AB, BB, YA, ZA (C, D, A, B) | water | water | 18.0 | 1662 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 261 (UniProt: Q16790)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 0 | - | expression tag |
| Ser 41 | Cys 174 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 112690.7 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3643.3 | |
| Non-Polymers* | Number of molecules | 42 |
| Total formula weight | 4416.4 | |
| All* | Total formula weight | 120750.4 |
