3I81
Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with BMS-754807 [1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoro-3-pyridinyl)-2-methyl-L-prolinamide]
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin-like growth factor 1 receptor | polymer | 315 | 35910.2 | 1 | UniProt (P08069) Pfam (PF07714) | Homo sapiens (human) | Insulin-like growth factor I receptor, IGF-I receptor |
| 2 | B (A) | 1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-N-(6-fluoropyridin-3-yl)-2-methyl-L-proli namide | non-polymer | 461.5 | 1 | Chemie (EBI) | |||
| 3 | C (A) | water | water | 18.0 | 225 | Chemie (HOH) |
Sequence modifications
A: 952 - 1256 (UniProt: P08069)
| PDB | External Database | Details |
|---|---|---|
| Met 950 | - | expression tag |
| Val 951 | - | expression tag |
| Met 1257 | - | expression tag |
| Glu 1258 | - | expression tag |
| Asn 1259 | - | expression tag |
| Asn 1260 | - | expression tag |
| Pro 1261 | - | expression tag |
| Val 1262 | - | expression tag |
| Leu 1263 | - | expression tag |
| Ala 1264 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35910.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 461.5 | |
| All* | Total formula weight | 36371.7 |
