3HZ1

Crystal structure of Hsp90 with fragments 37-D04 and 42-C03

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Heat shock protein HSP 90-alpha	polymer	249	27959.3	1	UniProt (P07900) Pfam (PF13589) In PDB	Homo sapiens (human)	HSP 86, Renal carcinoma antigen NY-REN-38
2	A	N,N-dimethyl-7H-purin-6-amine	non-polymer		163.2	1	Chemie (42C)
3	A	methyl 5-furan-2-yl-3-methyl-1H-pyrazole-4-carboxylate	non-polymer		206.2	1	Chemie (37D)
4		water	water		18.0	183	Chemie (HOH)

Sequence modifications

A: 9 - 236 (UniProt: P07900)

PDB	External Database	Details
Met -12	-	expression tag
Gly -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
Ser -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag
Leu 1	-	expression tag
Val 2	-	expression tag
Pro 3	-	expression tag
Arg 4	-	expression tag
Gly 5	-	expression tag
Ser 6	-	expression tag
His 7	-	expression tag
Met 8	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	27959.3
Non-Polymers*	Number of molecules	2
	Total formula weight	369.4
All*	Total formula weight	28328.7

*Water molecules are not included.