3HVG
Structure of bace (beta secretase) in Complex with EV0
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Beta-secretase 1 | polymer | 411 | 45794.4 | 3 | UniProt (P56817) Pfam (PF00026) | Homo sapiens (human) | BBACE1, eta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Membrane-associated aspartic protease 2, Memapsin-2, Aspartyl protease 2, Asp 2, ASP2 |
| 2 | D, E, F (A, B) | 2-amino-6-propylpyrimidin-4(3H)-one | non-polymer | 153.2 | 3 | Chemie (EV0) | |||
| 3 | G (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | H, I, J (A, B, C) | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence modifications
A, B, C: -15 - 392 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Leu -18 | - | expression tag |
| Pro -17 | - | expression tag |
| Arg -16 | - | expression tag |
| Lys -5 | Arg 56 | engineered mutation |
| Thr -4 | Arg 57 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 137383.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 551.6 | |
| All* | Total formula weight | 137934.8 |
