3HP5
Crystal Structure of Human p38alpha complexed with a pyrimidopyridazinone compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 14 | polymer | 360 | 41343.2 | 1 | UniProt (Q16539) Pfam (PF00069) | Homo sapiens (human) | Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A |
| 2 | B (A) | 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one | non-polymer | 436.3 | 1 | Chemie (52P) | |||
| 3 | C, D (A) | 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine | non-polymer | 257.2 | 2 | Chemie (I46) | |||
| 4 | E (A) | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41343.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 950.7 | |
| All* | Total formula weight | 42293.9 |
