3HKI
Crystal structure of murine thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Thrombin light chain | polymer | 44 | 5105.7 | 2 | UniProt (P19221) Pfam (PF09396) | Mus musculus (mouse) | Coagulation factor II |
| 2 | B, E (B, E) | Thrombin heavy chain | polymer | 258 | 29795.5 | 2 | UniProt (P19221) Pfam (PF00089) | Mus musculus (mouse) | Coagulation factor II |
| 3 | C, F (C, F) | Proteinase-activated receptor 1 | polymer | 21 | 2673.9 | 2 | UniProt (P25116) | Homo sapiens (human) | PAR-1, Thrombin receptor, Coagulation factor II receptor |
| 4 | G, H (B, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | I, J, K, L, M... (A, B, C, D, E...) | water | water | 18.0 | 217 | Chemie (HOH) |
Sequence modifications
B, E: 16 - 246 (UniProt: P19221)
| PDB | External Database | Details |
|---|---|---|
| Ala 215 | Trp 587 | engineered mutation |
| Ala 217 | Glu 589 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 75150.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 75592.5 |
