3HII
Crystal structure of human diamine oxidase in complex with the inhibitor pentamidine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Amiloride-sensitive amine oxidase | polymer | 731 | 83463.8 | 2 | UniProt (P19801) Pfam (PF02727) Pfam (PF02728) Pfam (PF01179) In PDB | Homo sapiens (human) | Diamine oxidase, DAO, Amiloride-binding protein, ABP, Histaminase, Kidney amine oxidase, KAO |
2 | C | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
3 | D, E, F, G, H | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
4 | A, B | COPPER (II) ION | non-polymer | 63.5 | 2 | Chemie (CU) | |||
5 | A, B | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
6 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
7 | A, B | 1,5-BIS(4-AMIDINOPHENOXY)PENTANE | non-polymer | 340.4 | 2 | Chemie (PNT) | |||
8 | water | water | 18.0 | 916 | Chemie (HOH) |
Sequence modifications
A, B: 21 - 751 (UniProt: P19801)
PDB | External Database | Details |
---|---|---|
Arg 21 | Pro 21 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 166927.6 | |
Branched | Number of molecules | 6 |
Total formula weight | 2708.5 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1060.3 | |
All* | Total formula weight | 170696.5 |