3HHM
Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | polymer | 1091 | 127294.1 | 1 | UniProt (P42336) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | Homo sapiens (human) | PI3-kinase p110 subunit alpha, PtdIns-3-kinase p110, PI3K |
| 2 | B (B) | niSH2 p85alpha | polymer | 373 | 44262.5 | 1 | UniProt (P27986) Pfam (PF00017) Pfam (PF16454) | Homo sapiens | |
| 3 | C (A) | (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE | non-polymer | 428.4 | 1 | Chemie (KWT) PubChem (5691) PubChem (44155625) PubChem (44283298) PubChem (44388158) PubChem (363060) PubChem (70846633) PubChem (71094029) PubChem (73897916) PubChem (58919665) PubChem (71109225) PubChem (3003565) PubChem (312145) PubChem (124543094) PubChem (124583470) PubChem (95566344) PubChem (6604048) PubChem (6604834) PubChem (6713132) PubChem (142863033) PubChem (125039846) PubChem (125039847) PubChem (162901955) PubChem (129010046) PubChem (129010429) PubChem (134688220) PubChem (162901956) PubChem (162901957) PubChem (162901958) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A: 1 - 1068 (UniProt: P42336)
B: 322 - 694 (UniProt: P27986)
| PDB | External Database | Details |
|---|---|---|
| Met -28 | - | expression tag |
| Ser -27 | - | expression tag |
| Tyr -26 | - | expression tag |
| Tyr -25 | - | expression tag |
| His -24 | - | expression tag |
| His -23 | - | expression tag |
| His -22 | - | expression tag |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| Asp -18 | - | expression tag |
| Tyr -17 | - | expression tag |
| Pro -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Trp -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ile -2 | - | expression tag |
| His -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Arg 1047 | His 1047 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 330 | Asp 330 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 171556.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 428.4 | |
| All* | Total formula weight | 171985.0 |
