3HA6
Crystal structure of aurora A in complex with TPX2 and compound 10
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase 6 | polymer | 268 | 31253.7 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (human) | Aurora kinase A, Aurora-A, Serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase |
| 2 | B | Targeting protein for Xklp2 | polymer | 44 | 4984.2 | 1 | UniProt (Q9ULW0) Pfam (PF09041) In PDB | Homo sapiens (human) | Restricted expression proliferation-associated protein 100, p100, Differentially expressed in cancerous and non-cancerous lung cells 2, DIL-2, Protein fls353, Hepatocellular carcinoma-associated antigen 519 |
| 3 | A | N~2~-(3,4-dimethoxyphenyl)-N~4~-[2-(2-fluorophenyl)ethyl]-N~6~-quinolin-6-yl-1,3,5-triazine-2,4,6-triamine | non-polymer | 511.6 | 1 | Chemie (2JZ) | |||
| 4 | water | water | 18.0 | 29 | Chemie (HOH) |
Sequence modifications
A: 125 - 391 (UniProt: O14965)
B: 1 - 43 (UniProt: Q9ULW0)
| PDB | External Database | Details |
|---|---|---|
| Gly 124 | - | EXPRESSION TAG |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36237.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 511.6 | |
| All* | Total formula weight | 36749.4 |
