3H9K
Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E | Thymidylate synthase | polymer | 313 | 35734.9 | 5 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (human) | TSase, TS |
| 2 | A, B, D | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE | non-polymer | 326.2 | 3 | Chemie (UFP) | |||
| 3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | C, D | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 5 | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 313 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| Lys 163 | Arg 163 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 178674.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1292.6 | |
| All* | Total formula weight | 179967.2 |
