3H54
Crystal Structure of human alpha-N-acetylgalactosaminidase,complex with GalNAc
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Alpha-N-acetylgalactosaminidase | polymer | 400 | 45582.9 | 2 | UniProt (P17050) Pfam (PF16499) Pfam (PF17450) In PDB | Homo sapiens (Human) | Alpha-galactosidase B |
2 | C | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
3 | D, F | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
4 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
5 | A, B | GLYCEROL | non-polymer | 92.1 | 15 | Chemie (GOL) | |||
6 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
7 | A, B | 2-acetamido-2-deoxy-alpha-D-galactopyranose | non-polymer | 221.2 | 2 | Chemie (A2G) | |||
8 | water | water | 18.0 | 655 | Chemie (HOH) |
Sequence modifications
A, B: 18 - 411 (UniProt: P17050)
PDB | External Database | Details |
---|---|---|
Gln 201 | Asn 201 | engineered mutation |
His 412 | - | expression tag |
His 413 | - | expression tag |
His 414 | - | expression tag |
His 415 | - | expression tag |
His 416 | - | expression tag |
His 417 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 91165.7 | |
Branched | Number of molecules | 4 |
Total formula weight | 3124.9 | |
Non-Polymers* | Number of molecules | 19 |
Total formula weight | 2266.2 | |
All* | Total formula weight | 96556.8 |