3H1P
Mature Caspase-7 I213A with DEVD-CHO inhibitor bound to active site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Caspase-7 | polymer | 260 | 29685.6 | 2 | UniProt (P55210) Pfam (PF00656) | Homo sapiens (human) | CASP-7, ICE-like apoptotic protease 3, ICE-LAP3, Apoptotic protease Mch-3, CMH-1 |
| 2 | C, D (C, D) | N-ACETYL-L-ALPHA-ASPARTYL-L-ALPHA-GLUTAMYL-N-[(2S)-1-CARBOXY-3-HYDROXYPROPAN-2-YL]-L-VALINAMIDE | polymer | 5 | 488.5 | 2 | BIRD (PRD_000422) | Homo sapiens | |
| 3 | E, F, G (A, B, D) | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
A, B: 50 - 303 (UniProt: P55210)
| PDB | External Database | Details |
|---|---|---|
| Ser 171 | Cys 171 | conflict |
| Ala 213 | Ile 213 | engineered mutation |
| His 304 | - | expression tag |
| His 305 | - | expression tag |
| His 306 | - | expression tag |
| His 307 | - | expression tag |
| His 308 | - | expression tag |
| His 309 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60348.1 | |
| All* | Total formula weight | 60348.1 |
