3H1D

Structure of the HUWE1 HECT Domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	E3 ubiquitin-protein ligase HUWE1	polymer	405	47424.6	1	UniProt (Q7Z6Z7) Pfam (PF00632) In PDB	Homo sapiens (human)
2	A	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
3		water	water		18.0	357	Chemie (HOH)

Sequence modifications

A: 3993 - 4374 (UniProt: Q7Z6Z7)

PDB	External Database	Details
Met 3970	-	expression tag
Gly 3971	-	expression tag
Ser 3972	-	expression tag
Ser 3973	-	expression tag
His 3974	-	expression tag
His 3975	-	expression tag
His 3976	-	expression tag
His 3977	-	expression tag
His 3978	-	expression tag
His 3979	-	expression tag
Ser 3980	-	expression tag
Ser 3981	-	expression tag
Gly 3982	-	expression tag
Leu 3983	-	expression tag
Glu 3984	-	expression tag
Val 3985	-	expression tag
Leu 3986	-	expression tag
Phe 3987	-	expression tag
Gln 3988	-	expression tag
Gly 3989	-	expression tag
Pro 3990	-	expression tag
His 3991	-	expression tag
Met 3992	-	expression tag
Ala 4099	Cys 4099	engineered mutation
Ala 4184	Cys 4184	engineered mutation
Ala 4367	Cys 4367	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	47424.6
Non-Polymers*	Number of molecules	4
	Total formula weight	384.3
All*	Total formula weight	47808.9

*Water molecules are not included.