3H11
Zymogen caspase-8:c-FLIPL protease domain complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CASP8 and FADD-like apoptosis regulator | polymer | 272 | 31450.2 | 1 | UniProt (O15519) Pfam (PF00656) | Homo sapiens (human) | |
| 2 | B (B) | Caspase-8 | polymer | 271 | 31001.1 | 1 | UniProt (Q14790) Pfam (PF00656) | Homo sapiens (human) | |
| 3 | C (C) | IETD aldehyde inhibitor | polymer | 5 | 531.6 | 1 | |||
| 4 | D, E (A, B) | water | water | 18.0 | 123 | Chemie (HOH) |
Sequence modifications
A: 209 - 480 (UniProt: O15519)
B: 202 - 464 (UniProt: Q14790)
| PDB | External Database | Details |
|---|---|---|
| Asn 369 | Asp 369 | SEE REMARK 999 |
| PDB | External Database | Details |
|---|---|---|
| Ala 359 | Asp 374 | engineered mutation |
| Ala 369 | Asp 384 | engineered mutation |
| Val 465 | - | expression tag |
| Glu 466 | - | expression tag |
| His 467 | - | expression tag |
| His 468 | - | expression tag |
| His 469 | - | expression tag |
| His 470 | - | expression tag |
| His 471 | - | expression tag |
| His 472 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 62982.9 | |
| All* | Total formula weight | 62982.9 |
