3H10
Aurora A inhibitor complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, D) | Serine/threonine-protein kinase 6 | polymer | 268 | 31047.7 | 3 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (human) | Aurora kinase A, Aurora-A, Serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase |
| 2 | D, E, F (A, B, D) | 9-chloro-7-(2,6-difluorophenyl)-N-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-5H-pyrimido[5,4-d][2]benzazepin-2-amine | non-polymer | 559.0 | 3 | Chemie (97B) | |||
| 3 | G, H, I (A, B, D) | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
A, B, D: 124 - 391 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Ala 124 | Lys 124 | engineered mutation |
| Ala 287 | Thr 287 | engineered mutation |
| Ala 288 | Thr 288 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 93143.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1677.0 | |
| All* | Total formula weight | 94820.2 |
