3H0Y
Aurora A in complex with a bisanilinopyrimidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase 6 | polymer | 268 | 31047.7 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (human) | Aurora kinase A, Aurora-A, Serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase |
| 2 | A | 2-chloro-N-[4-({5-fluoro-2-[(4-hydroxyphenyl)amino]pyrimidin-4-yl}amino)phenyl]benzamide | non-polymer | 449.9 | 1 | Chemie (48B) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A: 124 - 391 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Ala 124 | Lys 124 | engineered mutation |
| Ala 287 | Thr 287 | engineered mutation |
| Ala 288 | Thr 288 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31047.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 834.1 | |
| All* | Total formula weight | 31881.8 |
