3H0A
Crystal Structure of Peroxisome Proliferator-Activated Receptor Gamma (PPARg) and Retinoic Acid Receptor Alpha (RXRa) in Complex with 9-cis Retinoic Acid, Co-activator Peptide, and a Partial Agonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinoic acid receptor RXR-alpha | polymer | 228 | 25599.7 | 1 | UniProt (P19793) Pfam (PF00104) | Homo sapiens (Human) | Retinoid X receptor alpha, Nuclear receptor subfamily 2 group B member 1 |
| 2 | B (D) | Peroxisome proliferator-activated receptor gamma | polymer | 272 | 31094.1 | 1 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (Human) | PPAR-gamma, Nuclear receptor subfamily 1 group C member 3 |
| 3 | C, D (B, E) | Nuclear receptor coactivator 1, Co-activator Peptide | polymer | 12 | 1343.6 | 2 | UniProt (Q15788) | Homo sapiens | NCoA-1, Steroid receptor coactivator 1, SRC-1, RIP160, Protein Hin-2, Renal carcinoma antigen NY-REN-52 |
| 4 | E (A) | 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid | non-polymer | 348.5 | 1 | Chemie (9RA) | |||
| 5 | F (D) | [(4-{[2-(pent-2-yn-1-yloxy)-4-{[4-(trifluoromethyl)phenoxy]methyl}phenyl]sulfanyl}-5,6,7,8-tetrahydronaphthalen-1-yl)oxy]acetic acid | non-polymer | 570.6 | 1 | Chemie (D30) | |||
| 6 | G, H, I (A, D, E) | water | water | 18.0 | 105 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 59381.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 919.1 | |
| All* | Total formula weight | 60300.1 |
