3GWC

Crystal structure of Mycobacterium tuberculosis thymidylate synthase X bound to FdUMP and FAD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Thymidylate synthase thyX	polymer	258	28699.4	8	UniProt (P66930) Pfam (PF02511) UniProt (by SIFTS) (P9WG57) In PDB	Mycobacterium tuberculosis	TS, TSase
2	A, B, C, D, E...	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	8	Chemie (FAD)
3	A, B, C, D, E...	5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE	non-polymer		326.2	8	Chemie (UFP)
4	C	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5		water	water		18.0	937	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 250 (UniProt: P66930)

PDB	External Database	Details
Leu 251	-	expression tag
Glu 252	-	expression tag
His 253	-	expression tag
His 254	-	expression tag
His 255	-	expression tag
His 256	-	expression tag
His 257	-	expression tag
His 258	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	229595.4
Non-Polymers*	Number of molecules	17
	Total formula weight	8985.9
All*	Total formula weight	238581.3

*Water molecules are not included.