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3GHV

Human dihydrofolate reductase Q35K/N64F double mutant inhibitor complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Dihydrofolate reductasepolymer18621383.61UniProt (P00374)
Pfam (PF00186)
Homo sapiens (human)
2B
(A)
N-({4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]phenyl}carbonyl)-L-glutamic acidnon-polymer476.51Chemie (GHC)
3C
(A)
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer745.41Chemie (NDP)
4D
(A)
GLYCEROLnon-polymer92.11Chemie (GOL)
5E, F, G, H, I...
(A)
SULFATE IONnon-polymer96.16Chemie (SO4)
6K
(A)
waterwater18.0384Chemie (HOH)
Sequence modifications
A: 1 - 186 (UniProt: P00374)
PDBExternal DatabaseDetails
Lys 35Gln 36engineered mutation
Phe 64Asn 65engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight21383.6
Non-Polymers*Number of molecules9
Total formula weight1890.4
All*Total formula weight23274.1
*Water molecules are not included.

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PDB entries from 2025-07-23

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