3GHV
Human dihydrofolate reductase Q35K/N64F double mutant inhibitor complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A (A) | Dihydrofolate reductase | polymer | 186 | 21383.6 | 1 | UniProt (P00374) Pfam (PF00186) | Homo sapiens (human) | |
2 | B (A) | N-({4-[(2-amino-6-ethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]phenyl}carbonyl)-L-glutamic acid | non-polymer | 476.5 | 1 | Chemie (GHC) | |||
3 | C (A) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | E, F, G, H, I... (A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
6 | K (A) | water | water | 18.0 | 384 | Chemie (HOH) |
Sequence modifications
A: 1 - 186 (UniProt: P00374)
PDB | External Database | Details |
---|---|---|
Lys 35 | Gln 36 | engineered mutation |
Phe 64 | Asn 65 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 21383.6 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1890.4 | |
All* | Total formula weight | 23274.1 |