3GHN
Crystal structure of the exosite-containing fragment of human ADAMTS13 (form-2)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | A disintegrin and metalloproteinase with thrombospondin motifs 13 | polymer | 419 | 46527.5 | 1 | UniProt (Q76LX8) Pfam (PF17771) Pfam (PF00090) Pfam (PF19236) Pfam (PF05986) In PDB | Homo sapiens (human) | ADAMTS-13, ADAM-TS 13, ADAM-TS13, von Willebrand factor-cleaving protease, vWF-cleaving protease, vWF-CP |
2 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
3 | C | beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose | branched | 326.3 | 1 | In PDB GlyTouCan (G36855WW) | |||
4 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
5 | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A: 287 - 685 (UniProt: Q76LX8)
PDB | External Database | Details |
---|---|---|
Gly 285 | - | expression tag |
Arg 286 | - | expression tag |
Leu 524 | Ser 524 | engineered mutation |
Ser 686 | - | expression tag |
Arg 687 | - | expression tag |
Leu 688 | - | expression tag |
Glu 689 | - | expression tag |
Asn 690 | - | expression tag |
Leu 691 | - | expression tag |
Tyr 692 | - | expression tag |
Phe 693 | - | expression tag |
Gln 694 | - | expression tag |
Ser 695 | - | expression tag |
Arg 696 | - | expression tag |
Leu 697 | - | expression tag |
Glu 698 | - | expression tag |
Asn 699 | - | expression tag |
Leu 700 | - | expression tag |
Tyr 701 | - | expression tag |
Phe 702 | - | expression tag |
Gln 703 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 46527.5 | |
Branched | Number of molecules | 2 |
Total formula weight | 750.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 442.4 | |
All* | Total formula weight | 47720.7 |