3GEQ
Structural basis for the chemical rescue of Src kinase activity
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32640.5 | 2 | UniProt (P00523) Pfam (PF07714) In PDB | Gallus gallus (bantam chickens) | pp60c-src, p60-Src, c-Src |
2 | A, B | 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE | non-polymer | 302.8 | 2 | Chemie (PP2) | |||
3 | water | water | 18.0 | 221 | Chemie (HOH) |
Sequence modifications
A, B: 251 - 533 (UniProt: P00523)
PDB | External Database | Details |
---|---|---|
Gly 248 | - | expression tag |
His 249 | - | expression tag |
Met 250 | - | expression tag |
Ala 388 | Arg 388 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 65281.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 605.6 | |
All* | Total formula weight | 65886.6 |