3GEF

Crystal structure of the R482W mutant of lamin A/C

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Lamin-A/C	polymer	118	13094.6	4	UniProt (P02545) Pfam (PF00932)	Homo sapiens (human)	70 kDa lamin, Renal carcinoma antigen NY-REN-32
2	E, F, G, H (A, B, C, D)	water	water		18.0	320	Chemie (HOH)

Sequence modifications

A, B, C, D: 436 - 552 (UniProt: P02545)

PDB	External Database	Details
Ser 435	-	expression tag
Trp 482	Arg 482	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	52378.5
All*	Total formula weight	52378.5

*Water molecules are not included.