3GA3

Crystal structure of the C-terminal domain of human MDA5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Interferon-induced helicase C domain-containing protein 1, MDA5	polymer	133	15588.2	1	UniProt (Q9BYX4) Pfam (PF11648) In PDB	Homo sapiens (Human)	Interferon-induced with helicase C domain protein 1, Helicase with 2 CARD domains, Helicard, Melanoma differentiation-associated protein 5, MDA-5, RNA helicase-DEAD box protein 116, Murabutide down-regulated protein
2	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
3		water	water		18.0	204	Chemie (HOH)

Sequence modifications

A: 893 - 1017 (UniProt: Q9BYX4)

PDB	External Database	Details
Leu 1018	-	expression tag
Glu 1019	-	expression tag
His 1020	-	expression tag
His 1021	-	expression tag
His 1022	-	expression tag
His 1023	-	expression tag
His 1024	-	expression tag
His 1025	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	15588.2
Non-Polymers*	Number of molecules	1
	Total formula weight	65.4
All*	Total formula weight	15653.6

*Water molecules are not included.