3G9W

Crystal Structure of Talin2 F2-F3 in Complex with the Integrin Beta1D Cytoplasmic Tail

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Talin-2	polymer	223	25762.5	2	UniProt (Q71LX4) Pfam (PF00373) Pfam (PF02174)	Mus musculus (mouse)
2	C, D (C, D)	Integrin beta-1D	polymer	52	6190.2	2	UniProt (P05556) Pfam (PF08725)	Homo sapiens (human)	Fibronectin receptor subunit beta, Integrin VLA-4 subunit beta
3	E, F, H, I, K... (A, B, C)	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
4	G, J (A, B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
5	M, N, O, P (A, B, C, D)	water	water		18.0	381	Chemie (HOH)

Sequence modifications

A, B: 198 - 408 (UniProt: Q71LX4)

PDB	External Database	Details
Gly 186	-	expression tag
Ile 187	-	expression tag
Asp 188	-	expression tag
Pro 189	-	expression tag
Phe 190	-	expression tag
Thr 191	-	expression tag
Gly 192	-	expression tag
Ile 193	-	expression tag
Asp 194	-	expression tag
Pro 195	-	expression tag
Phe 196	-	expression tag
Thr 197	-	expression tag

C, D: 752 - 801 (UniProt: P05556)

PDB	External Database	Details
Gly 750	-	expression tag
Pro 751	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	63905.4
Non-Polymers*	Number of molecules	8
	Total formula weight	764.8
All*	Total formula weight	64670.2

*Water molecules are not included.