3G9R

Structure of the HIV-1 gp41 Membrane-Proximal Ectodomain Region in a Putative Prefusion Conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Fusion complex of HIV-1 Envelope glycoprotein and Saccharomyces cerevisiae General control protein GCN4	polymer	42	5415.4	6	UniProt (Q4QX39) UniProt (P03069) Pfam (PF07716) UniProt (by SIFTS) (P03377)	Human immunodeficiency virus 1
2	G, H, M, O, Q (A, B, C, D)	PHOSPHATE ION	non-polymer		95.0	5	Chemie (PO4)
3	I, J, K, L, N... (A, B, C, E)	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	8	Chemie (MPD)
4	T, U, V, W, X... (A, B, C, D, E...)	water	water		18.0	78	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 1 - 23 (UniProt: Q4QX39)
A, B, C, D, E, F: 24 - 42 (UniProt: P03069)

PDB	External Database	Details
Lys 27	Leu 261	engineered mutation
Ile 30	Asn 264	engineered mutation
Lys 31	Tyr 265	engineered mutation
Arg 32	His 266	engineered mutation
Ile 33	Leu 267	engineered mutation
Ile 37	Val 271	engineered mutation
Lys 38	Ala 272	engineered mutation
Ile 40	Leu 274	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	32492.3
Non-Polymers*	Number of molecules	13
	Total formula weight	1420.2
All*	Total formula weight	33912.5

*Water molecules are not included.