3G7W
Islet Amyloid Polypeptide (IAPP or Amylin) Residues 1 to 22 fused to Maltose Binding Protein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Maltose-binding periplasmic protein, Islet amyloid polypeptide fusion protein | polymer | 393 | 42929.6 | 1 | UniProt (P0AEX9) UniProt (P10997) Pfam (PF01547) Pfam (PF00214) | Escherichia coli | MMBP, Maltodextrin-binding protein, Amylin, Diabetes-associated peptide, DAP, Insulinoma amyloid peptide |
| 2 | B (B) | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 504.4 | 1 | In PDB BIRD (PRD_900009) GlyTouCan (G96370VA) | alpha-maltotriose | ||
| 3 | C, D, E, F, G... (A) | SULFATE ION | non-polymer | 96.1 | 20 | Chemie (SO4) | |||
| 4 | W, X (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | Y (A) | water | water | 18.0 | 366 | Chemie (HOH) |
Sequence modifications
A: 1 - 366 (UniProt: P0AEX9)
A: 371 - 392 (UniProt: P10997)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ala 359 | Glu 385 | engineered mutation |
| Ala 362 | Lys 388 | engineered mutation |
| Ala 363 | Asp 389 | engineered mutation |
| Asn 367 | - | linker |
| Ala 368 | - | linker |
| Ala 369 | - | linker |
| Ala 370 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42929.6 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 504.4 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 2105.4 | |
| All* | Total formula weight | 45539.4 |
